Comic Book Guy creates a superhero called "Everyman", which is turned into a feature film. Homer is cast as the lead, with Seth Rogen playing his personal trainer.
After one of Bart's pranks, Mrs. Krabappel is fired and replaced with a cool new teacher. But Bart is plagued by guilt.
The men and boys of Springfield become obsessed with Mixed Martial Arts. When Marge protests against the violent sport, the show's organiser challenges Marge to a match, promising to shut down if she wins.
Three more chilling stories: the family fights to survive a zombie outbreak after Krusty makes his hamburger out of mad cows; Bart and Lisa become entangled in a murder scheme; Homer's blood becomes the secret ingredient in Moe's new beer.
At the power plant, Carl is promoted and makes Homer his assistant. However, his working Homer too hard takes its toll on Homer and Marge's sex life.
Jonah Hill guest-voices as Andy Hamilton, a former Springfield Elementary student hailed as the best prankster ever.
Lisa befriends three Wiccans (one of whom played by Neve Campbell), who are accused of blinding the town with a spell. Meanwhile, Homer and Cletus make their own moonshine.
After realizing that Lisa and Maggie share a special bond because they are sisters, Bart yearns for a baby brother. He goes to the Springfield Orphanage to find what he thinks he's missing.
(Synopsis not completed yet.)
Krusty introduces a new character to his show, "Princess Penelope", to get more girls watching. He ends up falling in love with the actress who plays her (voiced by Anne Hathaway) but she soon upstages him. Jackie Mason also returns as Rabbi Krustofski.
Homer and Marge form a mixed-doubles curling team with Principal Skinner and his mother, Agnes. Marge turns out to be a good curler because of her expertise at household chores, while Homer is not very good. Marge must decide whether to risk hurting Homer's feelings by dropping him from the team. Meanwhile, Lisa sets out to collect Olympic pins.
The Simpsons get a new next-door neighbour, who turns out to be an old nemesis that's had a face transplant.
Homer wins a million dollars on the lottery. He hires Coldplay frontman Chris Martin to play a concert for Bart. This episode also features the winning character from 'The Simpsons Character Contest', Ricardo Bomba - a smooth-talking ladies’ man from South America with a luxurious black mane, a chiseled physique and a voice as smooth as silk.
(Synopsis not completed yet.)
Moe writes a revealing letter to three Springfield husbands with marriage troubles, saying that he has left town with one of their undisclosed wives. They're left to ponder who the unlucky one is.
The Simpsons take a church-group tour to the Holy Land in Israel. Sacha Baron Cohen plays an Israeli tour guide angered by the Simpsons, in particular Homer - who gets a case of Jerusalem Syndrome and believes that he is the messiah.
(Synopsis not completed yet.)
With The Simpsons' 21st Season (2009-2010), the show surpassed Gunsmoke as the longest running American prime-time series.
Guest stars include: Neve Campbell, Anne Hathaway, Seth Rogen, Jackie Mason (as Rabbi Krustofski), Sarah Silverman, Coldplay's Chris Martin and Jordan Nagai, the kid from Pixar's "Up".
Seth Rogen and Evan Goldberg, writers of the film Superbad, have written an episode: Comic Book Guy creates a super hero and it's turned into feature film in which Homer plays the hero.